Searchable abstracts of presentations at key conferences in endocrinology

ea0009p116 | Endocrine tumours and neoplasia | BES2005

The dynamics of GH secretion in adult cancer survivors with severe radiation-induced GH deficiency

Darzy K , Pezzoli S , Thorner M , Shalet S

We have used a sensitive chemiluminescence GH assay to analyse 24-hour GH profiles (20 minute sampling) from 11 adult cancer survivors with severe GH deficiency acquired following brain irradiation in childhood for non-pituitary brain tumours and 30 matched healthy normal volunteers. Cluster analysis revealed that the area under the curve for GH (AUCGH), absolute (maximum) GH peak height, mean peak height, maximum pulse area, mean pulse area, absolute (minimum) nadi...